János Szebeni, MD, PhD, DSc
CEO and Chief Scientist
Dr. János Szebeni, MD, PhD, DSc, Med. Habil., immunologist, co-founder and CEO of SeroScience Ltd. is also director of the Nanomedicine Research and Education Center at Semmelweis University in Budapest and full professor of immune biology at Miskolc University in Miskolc, Hungary. He has held various guest professor and scientific positions in Hungary and the United States where he lived for 22 years. His research on various themes in hematology, membrane biology and immunology resulted in over 150 publications including peer-reviewed papers, book chapters, patents, and a book entitled “The Complement System: Novel Roles in Health and Disease” (Kluwer, 2004). He was primary investigator in more than a dozen European and Hungarian research grants and over 30 CRO projects over the past 10 years. Dr. Szebeni is a regular speaker at international conferences and seminars with over 60 presentations in the past five years. He is also an ad hoc consultant for the United States Food and Drug Administration (FDA). Three fields stand out where he has been most active: artificial blood, liposomes and the complement system. His original work led to the CARPA concept, i.e., that complement activation underlies numerous drug-induced (pseudo)allergic infusion reactions. CARPA has been included in a recent European Medicines Agency (EMA) guideline as a recommended preclinical safety test.
László Rosivall, MD, PhD, DSc
László Rosivall, MD, PhD, DSc, full professor, is co-founder of SeroScience Ltd. Dr. Rosivall is currently head of the International Nephrology Research and Training Center, and the PhD School of Basic Medical Sciences at Semmelweis University. He is former head of Department of Pathophysiology, and has also served as Rector of the Semmelweis University. During his extensive academic and teaching career, among other things, Dr. Rosivall pioneered recognizing and characterizing the intrarenal renin-angiotensin system (RAS). Using nanotechnology he visualized the glomerular filration rate (GFR) in vivo and discovered a new, short loop feedback mechanism in its regulation, which refined fundamental knowledge of several basic renal physiological issues. He is also a Széchény prize laurate.
Rudolf Urbanics, MD, PhD
Head of Research (in vivo)
Rudolf Urbanics, MD, PhD, Head of the SeroScience in vivo laboratory obtained his MD at Semmelweis Medical School, and his PhD degree at the Hungarian Academy of Sciences. Dr. Urbanics held teaching and research positions at the Semmelweis University and held various research positions at the Max Planck Society, Institute of Systemic Physiology in Dortmund, Germany, at the University of Pennsylvania, Philadelphia, at Pennsylvania Muscle Institute, and at the Central Nervous System Research Department of Knoll AG. His work encompassed the field of CNS regulation of blood flow/metabolism, ischemic/hypoxic disorders, stroke and chronic neurodegenerative disease models. He was Deputy R&D Director and Head of CNS Pharmacology at Biorex Ltd., in Budapest, Hungary and also worked at IVAX/Drug Research Institute Budapest, as Scientific Advisor and Leading Researcher in Safety and CNS Pharmacology.
Gergely Tibor Kozma, PhD
Head of Research (in vitro)
Gergely Tibor Kozma, MSc, PhD, immunologist, is head of research of the in vitro laboratory of SeroScience Ltd., Budapest, Hungary. He received his MSc in bioengineering at the Technical University, Budapest, Faculty of Chemical Technology and Biotechnology; thereafter he obtained his PhD in immunology and molecular biology at Semmelweis University. He worked at Semmelweis University as well as several private companies as a researcher studying the immunological mechanisms of allergy and nano-drug induced hypersensitivity. Dr. Kozma spent 1.5 years in Rome, Italy as a postdoctoral researcher sponsored by the Marie Curie Research Training Network to investigate the antigen presenting processes of dendritic cells. In addtition to research, he was also involved in assay development in the field of monoclonal antibody production, ELISAs and protein engineering in E. coli. He is also a specialist of immune cells phenotyping by flow cytometry. His current field of research is the immunological study of nano-drug induced hypersensitivity reactions primarily complement activation related processes and immunogenicity. He has co-authored 20 original papers, with more than 700 citations.
László Dézsi, PhD, DrHabil
László Dézsi, PhD, Dr Habil., is a research fellow at SeroScience Ltd. and he is adjunct professor at the Nanomedicine Research and Education Center, Semmelweis University, Budapest, Hungary. He received his MSc in biology at Eötvös Loránd University, Budapest and obtained his PhD and habilitation in physiology at Semmelweis University. Dr. Dézsi was senior research associate at the 2nd Department of Physiology, Semmelweis University, and visiting scientist at Albert Ludwigs Universität, Freiburg, Germany and at University of Pennsylvania, Philadelphia. He worked for Gedeon Richter Pharmaceutical Plc. for 13 years and was manager of Analgesic Research Laboratory of Richter Plc. and the University of Pécs, Hungary. He was course director of the Biomedical Engineering course at Budapest University of Technology and Economics, and is currently course director of “Cardiorespiratory and Neurophysiological Measuring Techniques” at Semmelweis University. His current field of research is complement activation related pseudoallergy (CARPA). Dr. Dézsi has published 51 original papers and 11 book chapters.
Gyula Tamás Fülöp
Researcher, PhD student
Gyula Tamás Fülöp is a research fellow at SeroScience Ltd., Budapest, Hungary. He is a PhD student at the Nanomedicine Research and Education Center at Semmelweis Medical University of Budapest, Hungary. He got his bachelor and also master degree on the medical and pharmaceutical biotechnology program at the University of applied sciences Krems, Austria. He had a training semester in 2010 at the Academic Medical Center (AMC) Amsterdam, the Netherlands; and later in 2012 another training semester at Centro de Investigationes Biologicas (CSIC) Madrid, Spain. He will finish his PhD program this year in Budapest, where he is currently studying complement related infusion reactions of liposomal and other nanomedicine products.
Researcher, PhD student
Tamás Mészáros, MSc, is a research fellow at SeroScience Ltd., Budapest, Hungary since 2009. He received his MSc degree as an immunologist from Eötvös Lóránd University, Budapest, Hungary in the same year. He is currently pursuing his PhD degree at Semmelweis University and working on CRO projects, specifically in vitro research and development. His current field of research is the immunological study of nano-drug induced hypersensitivity reactions primarily complement activation related processes and immunogenicity. His special skills include in vitro ELISA assays and techniques. He has co-authored 16 original papers, with more than 100 citations.
Researcher, PhD student
Erik Őrfi is a research fellow at SeroScience Ltd., Budapest, Hungary. He acquired his MSc. and Pharm.D degrees at Semmelweis University Faculty of Pharmacy. During his industrial practice at Servier Pharmaceuticals he investigated NCE (new chemical entity) and did structure confirmations by NMR, UV/IR, Raman spectroscopy and X-ray crystallography. His further experiences include pharmacy management, GLP and quality control. He is currently a PhD student at Nanomedicine Research and Education Center at Semmelweis University. He is performing in vivo CARPA experiments on pigs, rats and mice. He is focusing on the mice model, where he is researching novel parameters of CARPA to characterize this phenomenon more precisely. He enjoys being a real teamplayer at the company and takes part in the CRO projects and project management.
Mária Velkei-Harvichné is a research assistant at Seroscience Ltd., Budapest, Hungary. She has nearly 40 years of work experience in the medical research field. She worked as a research assistant from 1974 to 2005 at the Clinical research and human life sciences institute at Semmelweis University, Hungary in the field of heart and brain circulation measurements. Between 2006 and 2007 she worked as a laboratory assistant in the field of biochemical studies, cell cultures and administration at the life science institute. From 2007 for 7 years she worked at Richter Gedeon co., in the field of migraine research and obesity studies. From 2014 she works at Seroscience co. as a research assistant in “in vivo” studies.